CELE_T25G3.2, chs-2, chi-1, T25G3.2

chs-1 encodes a chitin synthase, paralogous to CHS-2; chs-1 is required for embryonic chitin synthesis, eggshell synthesis and osmotic integrity, error-free chromosomal segregation during meiosis, polar body extrusion, association of the sperm pronucleus/centrosome complex (SPCC) with the early embryonic cortex, localization of PAR-2 in early embryos, posterior localization of P granules or PIE-1, and pseudocleavage; CHS-1 is also, independently of chitin synthesis, required for normal localization of MBK-2 to cortex and punctae in early embryos; CHS-1 is dispensable for synthesis of pharyngeal cuticle, since chs-1(ok1120) mutants have it normally; CHS-1 localizes to the oocyte plasma membrane and .cell cortex

37950

6239