CELE_T27A1.6, tbx-12, Ce-tbx-12, T27A1.6

mab-9 encodes a member of the T-box family of transcriptional regulators containing a 200-amino acid T-box DNA-binding domain most similar to mouse Brachyury; mab-9 is involved in hindgut and male tail development, specifically affecting the fate of two posterior blast cells in the hindgut, B and F; in the male this results in a grossly abnormal tail lacking spicules, and renders them incapable of mating; in the hermaphrodite this results in hindgut defects; mab-9 may also be part of a network of T-box genes that includes tbx-8, tbx-9 and vab-7 and is important for the correct patterning of posterior cells in the developing embryo; mab-9 mutations also affect backward locomotion as a result of motor neuron axon guidance defects; MAB-9 localizes to the nucleus of B and F and their descendents during development and is also detected in the nuclei of all embryonically derived motor neurons.

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