CELE_F35H8.3, F35H8.3

zfp-2 encodes a zinc-finger transcription factor; loss of zfp-2 and lin-35/Rb results in almost complete sterility accompanied by defects in somatic gonad development and vulval morphology, as well as polyploidization of somatic cell nuclei; loss of zfp-2 activity by itself reveals that zfp-2 is also required for cosuppression, inhibition of RNAi of some genes, and wild-type levels of expression of a rol-6 extrachromosomal array; a zfp-2::GFP promoter fusion construct is expressed in vulval cells and all somatic gonad structures, such as the spermatheca, sheath cells, uterine cells and distal tip cells (DTCs).

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6239