CELE_R06F6.9, acbp-2, R06F6.9

acbp-2/ech-4 encodes a highly conserved protein containing a functional acyl-CoA-binding binding domain required for protein stability and ligand binding; previously described as containing an enoyl-CoA hydratase/isomerase (ECH) domain and a predicted N-terminal mitochondrial targeting signal; loss of ACBP-2/ECH-4 function affects B-oxidation of unsaturated fatty acids in vivo; in acbp-2 mutants several genes encoding involved in peroxisomal and mitochondrial B-oxidation are upregulated; contains 10% less triglycerides and 40% fewer lipid droplets; loss of ACBP-2 function increased lipid chain unsaturation by 1.25 times; ACBP-2 is transcriptionally regulated by nuclear hormone receptor (NHR-49); ACBP::GFP is expressed in intestine and in hypodermis of adult animals.

39978

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