CELE_F44F4.2, F44F4.2

egg-3 encodes a member of the protein tyrosine phosphatase-like (PTPL) family; EGG-3 activity is required for proper regulation of the cell surface and cortical rearrangements that occur during egg activation in response to sperm entry; EGG-3 physically interacts with EGG-4/5 and the MBK-2 kinase to sequester MBK-2 at the oocyte cortex prior to meiosis, thus preventing MBK-2 from phosphorylating its substrates, such as cytoplasmic MEI-1/katanin; EGG-3 initially localizes to the oocyte cortex, but during anaphase of meiosis I moves into the cytoplasm where it is degraded allowing for activation of MBK-2.

39987

6239