C47D12.8, CELE_C47D12.8

xpf-1 encodes an ortholog of the DNA repair protein XPF/ERCC4, which when mutated in humans leads to Xeroderma Pigmentosum (Complementation group F; OMIM:133520); xpf-1 is a core NER (Nuclear Excision Repair) factor (other members being xpa-1, xpg-1, and ercc-1); NER factors remove UV-induced DNA damage and have been demonstrated to be required for both the global genome repair (GGR) and transcription coupled repair (TCR) pathways; XPF-1 activity is essential for the survival of germ cells and somatic tissue following UV irradiation and is necessary for germ cells and embryos to survive even relatively low doses of UV irradiation; mutations in xpf-1, as well as the other NER factors, renders animals hypersensitive to UV light; xpf-1(RNAi) animals are also hypersensitive to ultraviolet radiation, with increased germ cell apoptosis and embryonic lethality; XPF-1 protein interacts with ERCC-1 (an ERCC1 ortholog) in yeast two-hybrid assays; xpf-1 is expressed broadly in both embryonic and postembryonic animals, and is required for embryonic development; xpf-1 is upregulated in dauers, and shares an operon with kel-1 and VF13D12L.3.

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