CELE_F19H8.3, F19H8.3

arl-3 encodes a member of the ARL (ADP-ribosylation factor(ARF)-like) family of proteins which are very similar to ARF proteins but lack the ability to stimulate ADP ribosylation by cholera toxin; an arl-3 deletion allele, tm1703, results in essentially wild-type animals that display slight defects in male mating behavior; ARL-3::GFP reporter fusions are expressed in ciliated neurons, where they localize throughout the cell; the arl-3 upstream regulatory region contains an X box sequence, a conserved 14 bp element that may serve as a binding site for DAF-19, an RFX-family transcription factor that controls ciliary gene expression; in yeast two-hybrid studies, ARL-3 interacts with UNC-119, a conserved, novel protein essential for neuronal development.

40402

6239