Caenorhabditis elegans
SMA-3
CELE_R13F6.9, R13F6.9
sma-3 encodes a Smad protein; during development, SMA-3 functions as part of a DBL-1/SMA-6 TGF-beta-related signaling pathway that controls body size and male tail sensory ray and spicule formation; sma-3, through this pathway, also regulates reproductive aging; studies have shown that a reduction of TGF-beta pathway genes extends reproductive span by maintaining oocyte and germline quality; sma-3 is widely expressed at all developmental stages, beginning during embryogenesis, continuing through all larval stages, and seen very strongly in adult hermaphrodites and males; a SMA-3::GFP is detected in the pharynx, intestine, and hypodermis and localizes to the nucleus; sma-3 expression in the hypodermis is necessary and sufficient for normal body size; SMA-3 can physically interact with the LIN-31 forkhead transcription factor.
GO Process (10)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [ISS]
- defense response to fungus [IMP]
- innate immune response [IMP]
- intracellular signal transduction [IMP]
- nematode larval development [IMP]
- nematode male tail tip morphogenesis [IMP]
- positive regulation of cell size [IMP]
- positive regulation of multicellular organism growth [IGI, IMP]
- positive regulation of organ growth [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Download Curated Data for this Protein
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- Interactors 18
- Interactions 19
- Network