Caenorhabditis elegans

CPG-2

CELE_B0280.5, B0280.5
cpg-2 encodes a chondroitin proteoglycan with six chitin-binding peritrophin-A domains and three mucin-like regions; CPG-2 is individually dispensable for normal embryonic development; however, CPG-2 and CPG-1 are jointly required for osmotic integrity of early embryos, error-free chromosomal segregation during meiosis, polar body extrusion, association of the sperm pronucleus/centrosome complex (SPCC) with the early embryonic cortex, localization of PAR-2 in early embryos, posterior localization of P granules or PIE-1, and pseudocleavage; CPG-2, like CPG-1, is covalently linked to chondroitin, which itself is required for vulval morphogenesis, polar-body extrusion, and separation of the eggshell from the embryonic plasma membrane; cpg-2 mRNA, like that of cpg-1, is expressed specifically in the adult hermaphrodite germ line and is bound by GLD-1; CPG-2 has 34 potential chondroitin attachment sites, four of them verified by mass spectrometry, and transgenic CPG-2 synthesized in mammalian cells carries chondroitin sulfate chains; CPG-2's multiple peritrophin-A domains may enable mechanical cross-linking of chitin.
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