CELE_ZK652.11, ZK652.11

cuc-1 encodes a copper chaperone orthologous to Saccharomyces cerevisiae Atx1p and the vertebrate ATOX1 proteins; by homology, CUC-1 copper chaperone is predicted to function in the cytosol by transferring copper to the CUA-1 ATPase for transport into the post-Golgi compartment; when overexpressed in S. cerevisiae atx1 mutants, a cuc-1 cDNA is able to complement observed growth defects on iron-depleted media suggesting that, in vivo, CUC-1 functions in intracellular copper ion trafficking; in C. elegans, loss of cuc-1 activity via RNAi in wild-type and mutant backgrounds results in reduced fat content, suggesting that cuc-1 also plays a role in lipid metabolism; a cuc-1::GFP promoter fusion is strongly expressed in the adult intestine and highly expressed in the hypodermal cells of the head and body regions in the L1 larval stage; cuc-1::GFP expression is not seen in the intestine of dauer larvae.

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