Caenorhabditis elegans
DCR-1
CELE_K12H4.8, eri-4, let-740, K12H4.8
dcr-1 encodes a bidentate ribonuclease that is homologous to E. coli RNAse III; DCR-1 is required both for RNA interference and for synthesis of small developmental RNAs; DCR-1 functions to process pre-miRNAs into their mature, 22-nt form; DCR-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to DCR-1 for endonucleolytic processing; DCR-1 is also required for fragmention of chromosomal DNA during apoptosis, and undergoes a CED-3 protease-mediated conversion from a ribonuclease to a deoxyribonuclease.
GO Process (23)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA]
- RNA catabolic process [IDA]
- RNA interference [IMP]
- RNA phosphodiester bond hydrolysis [IDA, IMP]
- RNA phosphodiester bond hydrolysis, endonucleolytic [IDA, IMP]
- apoptotic DNA fragmentation [IGI]
- apoptotic process [IMP]
- defense response [IMP]
- developmental process [IMP]
- dsRNA fragmentation [IDA]
- gene expression [IMP]
- gonad morphogenesis [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- meiotic chromosome segregation [IMP]
- meiotic nuclear division [IMP]
- nematode larval development [IMP]
- oviposition [IMP]
- positive regulation of primary miRNA processing [IMP]
- pre-miRNA processing [IMP]
- production of siRNA involved in RNA interference [IMP]
- regulation of development, heterochronic [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Download Curated Data for this Protein
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- Interactors 132
- Interactions 164
- Network