Caenorhabditis elegans
UNC-116
CELE_R05D3.7, khc-1, R05D3.7
unc-116 encodes a kinesin-1 heavy chain ortholog; UNC-116 is predicted to function as an anterograde microtubule-based motor and its activity is required for transport and localization of synaptic vesicle components and thus for normal locomotion and larval development; in addition, unc-116 is required for normal early translocation of the meiotic spindle to the oocyte cortex, cortical positioning of the meiosis II spindle, and polar body formation; in neurons, UNC-116 retrograde displacements are regulated by PTL-1/Tau; UNC-116 physically interacts with the kinesin light chain KLC-2 to form a kinesin-1 complex in vivo; an UNC-116::GFP fusion protein is widely expressed and seen in neurons, muscle, and the pharynx; in neurons, UNC-116::GFP exhibits diffuse localization that is excluded from the nucleus and depends upon wild-type activity of KLC-2.
GO Process (18)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- axon guidance [IBA]
- axonal fasciculation [IMP]
- body morphogenesis [IMP]
- cytoskeleton-dependent intracellular transport [IBA]
- dendrite development [IMP]
- embryo development ending in birth or egg hatching [IMP]
- establishment of meiotic spindle localization [IMP]
- establishment of meiotic spindle orientation [IMP]
- locomotion [IMP]
- meiotic cytokinesis [IMP]
- metabolic process [IDA]
- microtubule-based movement [IBA]
- polar body extrusion after meiotic divisions [IMP]
- positive regulation of necrotic cell death [IGI]
- protein catabolic process [IMP]
- protein localization [IBA]
- synaptic vesicle transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
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- Interactors 11
- Interactions 14
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