CELE_T05G5.3, ncc-1, T05G5.3

cdk-1 encodes a cyclin-dependent kinase, orthologous to and functionally interchangeable with CDC28 from S. cerevisiae; CDK-1 is required for cell-cycle progression through M phase in both meiosis and mitosis; in regulating progression through meiosis and the oocyte-to-egg transition, CDK-1 functions to regulate the activity of the MBK-2 DYRK2 family kinase that phosphorylates a number of substrates to promote the oocyte-to-egg transition; CDK-1 physically interacts with CYB-1 and CYB-3 and demonstrates cyclin-dependent kinase activity in vitro; CDK-1 expression is detected at high levels in embryos, but is also seen in larvae and adults; CDK-1 localizes to nuclei and to the cytoplasm.

41569

6239