CELE_K01G5.6, K01G5.6

The rib-2 gene encodes an ortholog of human EXT2; the family of EXT genes have GlcNAc transferase activities and are involved in the synthesis of heparin sulfate proteoglycans; rib-2 encodes an alpha 1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate; the RIB-2 protein interacts with RIB-1 and coexpression of RIB-2 and RIB-1 proteins in vitro results in glycosyltransferase and heparin sulphate polymerase activities; rib-2 is also required for proper embryonic development, suggesting that rib-2 and rib-1 are required for the biosynthesis of glycosaminoglycans during development.

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