Caenorhabditis elegans
FRG-1
CELE_ZK1010.3, ZK1010.3
frg-1 encodes the C. elegans ortholog of vertebrate facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1); FRG-1 binds F-actin in vitro and, as a multimer, exhibits actin-bundling activity; FRG-1 is expressed throughout the life cycle; in embryos, FRG-1 localizes to nucleoli and diffusely in the cytoplasm; in larvae and adults, FRG-1 also localizes to dense bodies in body wall muscle, specifically to the distal region of the dense body where actin filaments attach; FRG-1 localization to the distal portion of dense bodies requires ATN-1/alpha-actinin activity; overexpression of FRG-1 under the control of its own promoter disrupts adult ventral body wall muscle integrity.
GO Process (3)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
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- Interactors 5
- Interactions 5
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