CELE_Y45F10D.9, Y45F10D.9

sas-6 is a member of an evolutionarily conserved family of proteins containing a coiled-coil region and a novel PISA (present in SAS-6) motif conserved in similar proteins in at least eight other species that contain basal bodies or centrioles; SAS-6 activity, along with that of ZYG-1, SAS-4, SAS-5, and SPD-2, is essential for centriole duplication; SAS-6 functions in a dose-dependent manner and localizes to centriolar cylinders; SAS-6 co-localizes to centrioles with SAS-4 and SAS-5, and is mutually dependent upon SAS-5, with which it interacts physically, for centriolar localization; SAS-6 localization also requires the activity of the ZYG-1 kinase; in addition to the early embryo, SAS-6 is also detected in sperm; phosphorylation of SAS-6 is critical for centriole formation and thus for faithful cell division; the kinase ZYG-1 phosphorylates SAS-6 at serine 123 and this phosphorylation event is crucial for robust centriole formation and to ensure the maintenance of SAS-6 at the emerging centriole.

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