CELE_C37H5.8, mot-2, C37H5.8

hsp-6 encodes a nuclear-encoded mitochondrion-specific chaperone that is a member of the DnaK/Hsp70 superfamily of molecular chaperones; hsp-6 is involved in the mitochondrial unfolded protein response, as hsp-6 expression, normally broadly detected from the L1 larval through adult stages of development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-6 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development; loss of hsp-6 via RNAi in young adult hermaphrodites results in abnormal mitochondrial membrane potential and morphology, accompanied by reduction of ATP levels and reduced levels of mitochondrial proteins ATP-2, HSP-60, and CLK-1; in addition, hsp-6(RNAi) of adults disrupts gonadal function, motility, and pharyngeal pumping, as well as resulting in reduced lifespan; an HSP-6::GFP fusion protein localizes to mitochondria; HSP-6 levels are markedly reduced in aged worms.

43923

6239