CELE_K11G9.6, met-I, K11G9.6

mtl-1 encodes one of two C. elegans metallothioneins, small, cysteine-rich, metal-binding proteins; MTL-1 functions in metal detoxification and homeostasis and in stress adaptation; in addition, mtl-1 plays a role in regulating growth and fertility; mtl-1 is constitutively expressed in the terminal bulb of the pharynx and expression is induced in larval intestinal cells following exposure to cadmium, heat shock, while its expressed is repressed in response to P. aeruginosa infection; intestinal expression is dependent upon ELT-2, an intestine-specific GATA-type transcription factor; mtl-1 is upregulated by DAF-16 in daf-2 mutants.

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