CELE_C27H6.2, C27H6.2

ruvb-1 encodes a AAA+ ATPase orthologous to the RUVBL1 family of ATPases; ruvb-1 functions as a component of the TOR signaling pathway that promotes localization of the box C/D snoRNP complex to nucleoli, thus enabling robust protein synthesis; ruvb-1 mutations strongly suppress pha-4 mutations, suggesting that pha-4 and the CeTOR pathway antagonize one another to regulate larval development and adult lifespan; ruvb-1::gfp promoter fusions are expressed in most cells of the early embryo, but restricted to pharyngeal cells beginning at ~2-fold stage of embryogenesis.

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