CELE_K08F9.2, tag-216, K08F9.2

aipl-1 encodes a conserved WD-repeat protein that cooperates with ADF/cofilin and is highly homologous to AIP-1; the sequence of the encoded protein is 66% identical to UNC-78; aipl-1 and unc-78 have redundant and overlapping functions in organized assembly of actin filaments in embryonic muscle and the unc-78 and aipl-1 double mutant is embryonic lethal; both AIPL-1 isoforms preferentially cooperate with UNC-60B, a muscle-specific ADF/cofilin for actin filament disassembly in embryonic muscle; AIPL-1 affects localization of only F-actin-bound UNC-60B; AIPL-1 is expressed in the embryonic neurons, the intestine and the body wall muscle, in adult spermatheca and body wall muscles; AIPL-1 majorly functions in early embryonic muscle and can compensate for the function of UNC-78 in the body wall muscle.

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