CELE_C55B6.2, C55B6.2

dnj-7 encodes a protein containing a DnaJ domain that is orthologous to vertebrate P58IPK/DNAJC3, peripheral membrane proteins of the rough endoplasmic reticulum (ER) that function in co-translocational ER protein degradation during ER stress; in C. elegans, loss of dnj-7 activity via RNAi results in increased expression of an hsp-4::gfp (BiP) stress-inducible reporter fusion, suggesting that dnj-7 functions to regulate ER homeostasis.

45908

6239