CELE_C09F12.1, C09F12.1

clc-1 encodes a claudin homolog, closely similar to CLC-2, that is required for normal cohesion of apical junctions in epithelia; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water; CLC-1 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the pharynx to dyes; clc-1 is expressed in spermatheca, pharynx, intestine, hypodermis, the excretory-secretory system, and the cell-cell junctions of the vulva; in pharyngeal cells, CLC-1 colocalizes with AJM-1 in long thin lines, parallel to the pharyngeal axis and lining the lumenal surface, that appear to correspond with apical intercellular junctions.

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