CELE_F57B10.6, F57B10.6

xpg-1 encodes an ortholog of human XPG (also known as ERCC5; mutations in this gene are associated with Cockayne Syndrome; OMIM:133530); xpg-1 is a core NER (Nuclear Excision Repair) factor (other members being xpf-1, xpa-1, and ercc-1); NER factors remove UV-induced DNA damage and have been demonstrated to be required for both the global genome repair (GGR) and transcription coupled repair (TCR) pathways; XPG-1 activity is essential for the survival of germ cells and somatic tissue following UV irradiation and is necessary for germ cells and embryos to survive even relatively low doses of UV irradiation; mutations in xpg-1, as well as in other NER factors, render animals hypersensitive to UV light.

51181

6239