CELE_K07G5.2, rad-3, K07G5.2

xpa-1 encodes a DNA-binding protein orthologous to human XPA (which when mutated leads to Xeroderma Pigmentosum; OMIM:278700); xpa-1 is required for normal survival and resistance to mutagenesis in response to UV light, the extended lifespan of dauer-like mutants, and fertility; XPA-1 is required in UV-irradiated nondauer larvae to prevent WWP-1-mediated proteolysis of AMA-1; transgenic xpa-1 rescues the UV sensitivity of the null allele xpa-1(mn157); xpa-1 is a core NER (Nuclear Excision Repair) factor (other members being xpf-1, xpg-1, and ercc-1); xpa-1 is essential for the repair of UV-induced DNA lesions and has been demonstrated to be required in both the global genome repair (GGR) and transcription coupled repair (TCR) pathways; following UV irradiation, XPA-1 activity is essential for normal meiotic development, induction of germ cell apoptosis, and the survival of germ cells and somatic tissue (even at relatively low doses of UV irradiation); loss of xpa-1 activity via mutation or RNA-mediated interference (RNAi) renders animals hypersensitive to UV light at all stages of development; xpa-1 mRNA is detected in eggs and mixed stage populations.

51826

6239