CELE_F48F5.5, face-2, Ce-face-2, F48F5.5

fce-2 encodes an ortholog of 'farnesylated-proteins converting enzyme 2' (FACE-2), and thus probably enables post-translational processing of proteins (such as LET-60/RAS) carrying a C-terminal CaaX motif; FCE-2 protein probably accounts for the tosylphenylalanylchloromethane-sensitive, EDTA-insensitive component of CaaX-proteolytic activity in membrane extracts from C. elegans; FCE-2 can cleave a farnesylated peptide in vitro; Rce1p, the S. cerevisiae homolog of FCE-2, is directly involved in the C-terminal processing of farnesylated a-factor mating pheromone, and transgenic fce-2 rescues the mating defect of mutant yeast lacking both the Ste24p and the Rce1p CaaX-proteases.

532571

6239