Caenorhabditis elegans
CED-9
CELE_T07C4.8, T07C4.8
ced-9 encodes the sole C. elegans homolog of the mammalian cell-death inhibitor Bcl-2; during development, ced-9 activity is essential for preventing cells from undergoing programmed cell death; ced-9 also appears to have proapoptotic activity; CED-9 functions by binding and repressing the activity of CED-4, a protein similar to human APAF-1 and positive regulator of CED-3 caspase activity; CED-9 localizes to the mitochondrial outer membrane, although this localization is not essential for CED-9 to regulate apoptosis.
GO Process (10)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- apoptotic process [IMP]
- cell death [IMP]
- embryo development ending in birth or egg hatching [IMP]
- extrinsic apoptotic signaling pathway in absence of ligand [IBA]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA]
- negative regulation of apoptotic process [IBA, IGI, IMP]
- negative regulation of intrinsic apoptotic signaling pathway [IBA]
- negative regulation of programmed cell death [IMP]
- positive regulation of GTPase activity [IDA]
- positive regulation of mitochondrial fusion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
533094
6239
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- Interactors 15
- Interactions 68
- Network