CELE_Y48G9A.3, Y48G9A.3

gcn-1 encodes the C. elegans ortholog of the S. cerevisiae ribosome-associated protein Gcn1p; GCN-1, along with ABCF-3, is required for maintaining the steady-state levels of phosphorylated eIF2alpha, and thus for the translational control of a number of mRNAs; GCN-1 activity is required, in parallel to, or downstream of, the canonical apoptotic pathway, for apoptotic cell death of most somatic cells and germ cells in response to ionizing radiation; in addition, GCN-1 is required for normal growth rates, and spatial organization of germ cells in the gonad; as in S. cerevisiae, GCN-1 physically interacts with ABCF-3, the C. elegans ortholog of budding yeast Gcn20p, and GCN-1 and ABCF-3 are each required for the other's stability; a gcn-1::gfp promoter fusion is expressed in most cells, including germ cells, throughout development.

54650

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