Rattus norvegicus
IRS1
IRS1IRM
insulin receptor substrate 1
GO Process (28)
GO Function (10)
GO Component (9)
Gene Ontology Biological Process
- cellular response to insulin stimulus [ISO]
- insulin receptor signaling pathway [IDA, ISO]
- insulin secretion [ISO]
- insulin-like growth factor receptor signaling pathway [ISO, ISS]
- lipid catabolic process [ISO]
- mammary gland development [ISO]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of insulin secretion [IMP, ISO]
- negative regulation of somatostatin secretion [IMP]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of fatty acid beta-oxidation [ISO]
- positive regulation of glucagon secretion [IMP]
- positive regulation of glucose import [ISO]
- positive regulation of glucose import in response to insulin stimulus [ISO]
- positive regulation of glucose metabolic process [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of insulin receptor signaling pathway [IMP]
- positive regulation of mesenchymal cell proliferation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA, ISO]
- positive regulation of phosphorylation [IDA]
- protein heterooligomerization [IDA]
- protein kinase B signaling [ISO]
- protein localization to nucleus [ISO]
- regulation of gene expression [ISO]
- response to caffeine [IDA]
- response to insulin [ISO]
- response to peptide hormone [IDA]
Gene Ontology Molecular Function- SH2 domain binding [IPI]
- insulin receptor binding [IMP, ISO, ISS]
- insulin-like growth factor receptor binding [IPI, ISO, ISS]
- phosphatidylinositol 3-kinase binding [IDA, IMP, IPI, ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C binding [IPI]
- protein kinase binding [IPI, ISO]
- signal transducer activity [IBA]
- transmembrane receptor protein tyrosine kinase adaptor activity [IMP]
- SH2 domain binding [IPI]
- insulin receptor binding [IMP, ISO, ISS]
- insulin-like growth factor receptor binding [IPI, ISO, ISS]
- phosphatidylinositol 3-kinase binding [IDA, IMP, IPI, ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C binding [IPI]
- protein kinase binding [IPI, ISO]
- signal transducer activity [IBA]
- transmembrane receptor protein tyrosine kinase adaptor activity [IMP]
Gene Ontology Cellular Component
Download Curated Data for this Protein
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- Interactors 14
- Interactions 22
- Network
- PTM Sites 1