Rattus norvegicus
PIK3R1
PI3KA
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
GO Process (54)
GO Function (24)
GO Component (12)
Gene Ontology Biological Process
- B cell differentiation [ISO]
- NFAT protein import into nucleus [ISO]
- aging [IEP]
- cellular glucose homeostasis [ISO, ISS]
- cellular response to UV [ISO]
- cellular response to fatty acid [IEP]
- cellular response to insulin stimulus [IEP, ISO, ISS]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- glucose metabolic process [IMP]
- growth hormone receptor signaling pathway [ISO]
- insulin receptor signaling pathway [IMP, ISS]
- insulin-like growth factor receptor signaling pathway [IMP, ISO, ISS]
- intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of apoptotic process [ISO, ISS]
- negative regulation of blood pressure [IMP]
- negative regulation of cell-cell adhesion [IMP]
- negative regulation of cell-matrix adhesion [ISO]
- negative regulation of heart rate [IMP]
- negative regulation of muscle cell apoptotic process [IMP]
- negative regulation of osteoclast differentiation [ISO]
- negative regulation of proteolysis [IMP]
- negative regulation of smooth muscle cell proliferation [IMP]
- phosphatidylinositol 3-kinase signaling [ISO]
- phosphatidylinositol phosphorylation [ISS]
- phosphatidylinositol-3-phosphate biosynthetic process [IDA, TAS]
- positive regulation of RNA splicing [ISO, ISS]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of endoplasmic reticulum unfolded protein response [ISO, ISS]
- positive regulation of gene expression [IMP]
- positive regulation of myoblast differentiation [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transcription factor import into nucleus [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- positive regulation of tumor necrosis factor production [ISO]
- protein phosphorylation [ISO]
- protein stabilization [ISO, ISS]
- regulation of phosphatidylinositol 3-kinase activity [IDA]
- response to amino acid [IEP]
- response to cAMP [IDA]
- response to dexamethasone [IEP]
- response to drug [IEP]
- response to endoplasmic reticulum stress [ISO, ISS]
- response to estradiol [IEP]
- response to ethanol [IEP]
- response to fatty acid [IEP]
- response to fructose [IEP]
- response to glucocorticoid [IDA]
- response to growth factor [IEP]
- response to insulin [IDA]
- response to iron(II) ion [IEP]
- response to nutrient [IEP]
- response to progesterone [IEP]
- response to testosterone [IEP]
- response to yeast [IEP]
Gene Ontology Molecular Function- 1-phosphatidylinositol-3-kinase activity [IDA, TAS]
- 1-phosphatidylinositol-3-kinase regulator activity [IDA]
- ATPase binding [IPI]
- ErbB-3 class receptor binding [ISO, ISS]
- calmodulin binding [IPI]
- estrogen receptor binding [IPI]
- insulin binding [ISO]
- insulin receptor binding [ISO, ISS]
- insulin receptor substrate binding [IPI, ISO, ISS]
- insulin-like growth factor receptor binding [ISO, ISS]
- neurotrophin TRKA receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [IPI]
- phosphatidylinositol 3-kinase regulator activity [ISS]
- phosphoprotein binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein C-terminus binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- receptor binding [IPI]
- receptor tyrosine kinase binding [IPI]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [IPI]
- 1-phosphatidylinositol-3-kinase activity [IDA, TAS]
- 1-phosphatidylinositol-3-kinase regulator activity [IDA]
- ATPase binding [IPI]
- ErbB-3 class receptor binding [ISO, ISS]
- calmodulin binding [IPI]
- estrogen receptor binding [IPI]
- insulin binding [ISO]
- insulin receptor binding [ISO, ISS]
- insulin receptor substrate binding [IPI, ISO, ISS]
- insulin-like growth factor receptor binding [ISO, ISS]
- neurotrophin TRKA receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [IPI]
- phosphatidylinositol 3-kinase regulator activity [ISS]
- phosphoprotein binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein C-terminus binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- receptor binding [IPI]
- receptor tyrosine kinase binding [IPI]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Download Curated Data for this Protein
247545
10116
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- Interactors 10
- Interactions 18
- Network