Rattus norvegicus
SMAD3
Madh3, Smad 3, mad3
SMAD family member 3
GO Process (72)
GO Function (30)
GO Component (11)
Gene Ontology Biological Process
- SMAD protein complex assembly [IPI, ISO]
- SMAD protein signal transduction [ISO]
- T cell activation [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IMP]
- activin receptor signaling pathway [ISO]
- cell cycle arrest [ISO]
- cell-cell junction organization [ISO]
- developmental growth [ISO]
- embryonic cranial skeleton morphogenesis [ISO]
- embryonic foregut morphogenesis [ISO]
- embryonic pattern specification [ISO]
- endoderm development [ISO]
- evasion or tolerance of host defenses by virus [ISO]
- extrinsic apoptotic signaling pathway [ISO]
- gastrulation [ISO]
- heart looping [ISO]
- immune response [ISO]
- immune system development [ISO]
- in utero embryonic development [ISO]
- intracellular signal transduction [ISO]
- lens fiber cell differentiation [ISO]
- liver development [ISO]
- mesoderm formation [ISO]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IDA]
- negative regulation of inflammatory response [ISO]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of osteoblast differentiation [ISO]
- negative regulation of osteoblast proliferation [ISO]
- negative regulation of protein catabolic process [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of wound healing [ISO]
- nodal signaling pathway [ISO]
- osteoblast development [ISO]
- osteoblast differentiation [ISO]
- paraxial mesoderm morphogenesis [ISO]
- pericardium development [ISO]
- positive regulation of alkaline phosphatase activity [IDA]
- positive regulation of bone mineralization [IDA]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of catenin import into nucleus [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of chondrocyte differentiation [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of focal adhesion assembly [IDA]
- positive regulation of gene expression [ISO]
- positive regulation of interleukin-1 beta production [IMP]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of stress fiber assembly [IDA]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of transforming growth factor beta3 production [IMP]
- protein stabilization [ISO]
- regulation of binding [ISO]
- regulation of epithelial cell proliferation [ISO]
- regulation of immune response [ISO]
- regulation of striated muscle tissue development [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transforming growth factor beta receptor signaling pathway [ISO]
- regulation of transforming growth factor beta2 production [ISO]
- response to hypoxia [ISO]
- signal transduction involved in regulation of gene expression [IMP]
- skeletal system development [ISO]
- somitogenesis [ISO]
- thyroid gland development [ISO]
- transdifferentiation [IDA]
- transforming growth factor beta receptor signaling pathway [IMP, ISO]
- transport [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISO]
- SMAD binding [IPI]
- bHLH transcription factor binding [ISO]
- beta-catenin binding [ISO]
- chromatin DNA binding [ISO]
- chromatin binding [ISO]
- co-SMAD binding [ISO]
- collagen binding [ISO]
- core promoter proximal region sequence-specific DNA binding [ISO, ISS]
- double-stranded DNA binding [ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IDA, IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase binding [ISO]
- zinc ion binding [ISO]
- DNA binding [IDA]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISO]
- SMAD binding [IPI]
- bHLH transcription factor binding [ISO]
- beta-catenin binding [ISO]
- chromatin DNA binding [ISO]
- chromatin binding [ISO]
- co-SMAD binding [ISO]
- collagen binding [ISO]
- core promoter proximal region sequence-specific DNA binding [ISO, ISS]
- double-stranded DNA binding [ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IDA, IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
Download Curated Data for this Protein
247660
10116
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- Interactors 3
- Interactions 4
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