Rattus norvegicus
HES1
hes family bHLH transcription factor 1
GO Process (75)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- Notch signaling pathway [ISO]
- STAT protein import into nucleus [ISO, ISS]
- adenohypophysis development [ISO]
- aorta morphogenesis [ISO]
- artery morphogenesis [ISO]
- ascending aorta morphogenesis [ISO]
- auditory receptor cell differentiation [ISO]
- auditory receptor cell fate determination [ISO]
- cardiac neural crest cell development involved in outflow tract morphogenesis [ISO]
- cell adhesion [ISO]
- cell fate commitment [ISO]
- cell maturation [ISO]
- cell migration [ISO]
- cell morphogenesis involved in neuron differentiation [ISO]
- cochlea development [ISO]
- common bile duct development [ISO]
- embryonic heart tube morphogenesis [ISO]
- forebrain radial glial cell differentiation [IDA]
- hindbrain morphogenesis [ISO]
- in utero embryonic development [ISO]
- labyrinthine layer blood vessel development [ISO]
- lateral inhibition [ISO]
- liver development [ISO]
- lung development [ISO]
- midbrain development [ISO]
- midbrain-hindbrain boundary morphogenesis [ISO]
- negative regulation of auditory receptor cell differentiation [ISO]
- negative regulation of cell differentiation [ISO]
- negative regulation of forebrain neuron differentiation [IDA]
- negative regulation of gene expression [IMP]
- negative regulation of glial cell proliferation [ISO, ISS]
- negative regulation of inner ear receptor cell differentiation [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of oligodendrocyte differentiation [ISO, ISS]
- negative regulation of pancreatic A cell differentiation [ISO]
- negative regulation of pro-B cell differentiation [ISO, ISS]
- negative regulation of stem cell differentiation [ISO]
- negative regulation of stomach neuroendocrine cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neural tube development [ISO]
- neuronal stem cell maintenance [IDA, ISO]
- oculomotor nerve development [ISO]
- outflow tract morphogenesis [ISO]
- pancreas development [ISO]
- pattern specification process [ISO]
- pharyngeal arch artery morphogenesis [ISO]
- pituitary gland development [ISO]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of DNA binding [ISO, ISS]
- positive regulation of JAK-STAT cascade [ISO, ISS]
- positive regulation of Notch signaling pathway [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of astrocyte differentiation [ISO, ISS]
- positive regulation of cell proliferation [ISO]
- positive regulation of mitotic cell cycle, embryonic [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO, ISS]
- protein complex assembly [ISO, ISS]
- regulation of fat cell differentiation [ISO]
- regulation of neurogenesis [ISO]
- regulation of secondary heart field cardioblast proliferation [ISO]
- regulation of timing of cell differentiation [ISO]
- regulation of timing of neuron differentiation [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- smoothened signaling pathway [ISO]
- somatic stem cell maintenance [ISO]
- telencephalon development [ISO]
- thymus development [ISO]
- transcription from RNA polymerase II promoter [ISO]
- trochlear nerve development [ISO]
- vascular smooth muscle cell development [ISO]
- ventricular septum development [ISO]
- ventricular septum morphogenesis [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- E-box binding [IDA]
- N-box binding [ISO, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO, ISS]
- chaperone binding [ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [IPI]
- DNA binding [ISO]
- E-box binding [IDA]
- N-box binding [ISO, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO, ISS]
- chaperone binding [ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- cytoplasm [ISO]
- intracellular [ISO]
- nucleoplasm [ISO, TAS]
- nucleus [ISO, ISS]
Download Curated Data for this Protein
248210
10116
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- Interactors 8
- Interactions 9
- Network