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Saccharomyces cerevisiae (S288c)

DHH1

DExD/H-box ATP-dependent RNA helicase DHH1, L000000504, YDL160C

Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, role in translational repression, mRNA decay, and processing body dynamics; may have a role in mRNA export; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress

GO Process (5)

GO Function (5)

GO Component (3)

Gene Ontology Biological Process

cytoplasmic mRNA processing body assembly [IGI, IMP]

deadenylation-dependent decapping of nuclear-transcribed mRNA [IMP]

negative regulation of translation [IMP]

negative regulation of translational elongation [IGI, IMP]

stress granule assembly [IMP]

Gene Ontology Molecular Function

ATP-dependent RNA helicase activity [ISS]
chromatin binding [IDA]
mRNA binding [IDA]
protein binding [IPI]
translation regulator activity, nucleic acid binding [IGI, IMP]

Gene Ontology Cellular Component

cytoplasm [IDA]

cytoplasmic mRNA processing body [IDA]

cytoplasmic stress granule [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

31903

559292

Interactors 3,633
Interactions 5,143
Network
PTM Sites 4