CELE_K10D3.2, K10D3.2

unc-14 encodes a RUN (RPIP8, UNC-14, and NESCA) domain-containing protein; unc-14 activity is required for axonogenesis (neurite outgrowth and axonal transport) and sex myoblast migration; in regulating axon guidance, UNC-14 functions together with the UNC-51 kinase, which binds and phosphorylates UNC-14, to properly localize the UNC-5 netrin receptor; UNC-14 also interacts with the kinesin light chain KLC-2 and thus appears to function as an adaptor protein that mediates kinesin-1-dependent transport of synaptic vesicle components; an UNC-14::GFP reporter fusion is expressed in neurons, including the VD and DD motor neurons, where it localizes to puncta in the axons or cell bodies; UNC-14 localization is dependent upon kinesin-1 (UNC-116 and KLC-2).

37895

6239