CELE_F46A9.6, F46A9.6

mec-8 encodes a protein with two RNA recognition motifs (RRM); mec-8 is required for proper development of body wall muscle and chemosensory and touch receptor neurons and as a result, for embryonic and larval development, sensory neuron fasciculation, and mechanosensation; MEC-8 functions as an mRNA processing factor whose activity is required for alternative splicing of genes such as unc-52/perlecan, with which it interacts genetically to produce synthetic lethality at the two-fold stage of embryonic elongation; mec-8 mutations also exhibit synthetic lethality with mutations in a number of other genes, including the sym genes and daf-18; mec-8; unc-52 synthetic lethality is suppressed by mutations in smu-1 and smu-2 which both encode homologs of mammalian spliceosome-associated proteins; mec-8 is broadly expressed in the embryo and expressed in hypodermal and neuronal tissues in larvae.

38199

6239