Caenorhabditis elegans
SKR-2
CELE_F46A9.4, F46A9.4
skr-2 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-2 is required for the restraint of cell proliferation, progression through the pachytene stage of meiosis, and the formation of bivalent chromosomes at diakinesis; SKR-2::GFP is detected exclusively in the intestine.
GO Process (14)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- apoptotic process [IMP]
- determination of adult lifespan [IMP]
- embryo development ending in birth or egg hatching [IMP]
- establishment of mitotic spindle orientation [IMP]
- gonad development [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- meiotic chromosome segregation [IMP]
- meiotic nuclear division [IMP]
- negative regulation of cell proliferation [IMP]
- nematode larval development [IMP]
- oviposition [IMP]
- regulation of meiotic cell cycle [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
38201
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- Interactors 49
- Interactions 67
- Network