Caenorhabditis elegans
MOM-4
CELE_F52F12.3, F52F12.3
mom-4 encodes a MAP kinase kinase kinase-related protein orthologous to Drosophila Tak1 and the vertebrate MAPKKK7 proteins; during embryonic development, mom-4 activity is required for positive regulation of the Wnt pathway signaling that governs anterior/posterior (A/P) polarity: MOM-4 stimulates the WRM-1/LIT-1-dependent phosphorylation of POP-1, a TCF/LEF-related transcription factor, leading to its downregulation in posterior daughters of A/P cell divisions.
GO Process (10)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- MAPK cascade [IDA]
- activation of MAPKK activity [IDA]
- asymmetric cell division [IMP]
- asymmetric protein localization involved in cell fate determination [IMP]
- defense response [IMP]
- embryo development ending in birth or egg hatching [IMP]
- endodermal cell fate specification [IMP]
- muscle cell fate specification [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
38265
6239
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- Interactors 12
- Interactions 17
- Network