CELE_C47B2.5, C47B2.5

eif-6 encodes the C. elegans ortholog of vertebrate anti-association factor eIF6 and Saccharomyces cerevisiae Tif6p; EIF-6 is required for lin-4 miRNA-mediated repression of lin-14 and lin-28 mRNA and protein levels and in addition, is required for normal rates of growth and control of cell division in the germ line; eif-6 is expressed ubiquitously (or nearly so) in somatic larval and adult tissues; by orthology to eIF6 and Tif6p, EIF-6 is predicted to be recycled by K10C3.5 and W06E11.4 during maturation of 60S ribosomal subunits, suggesting a link between ribosome assembly and several processes, including miRNA-mediated gene silencing, germline proliferation, and regulation of growth rates; EIF-6 may suppress tumorous growth in the germ line by ensuring robust larval germline proliferation.

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