Caenorhabditis elegans
PRY-1
CELE_C37A5.9, C37A5.9
pry-1 encodes a protein containing RGS and DIX domains that is distantly related to members of the Axin family of proteins that function as part of a complex that targets beta-catenin for destruction in the absence of Wnt signaling; during C. elegans development, PRY-1 functions as a negative regulator of Wnt signaling pathways that specify cell fates during asymmetric cell division; in addition, pry-1 has been shown to have a role in axon guidance; PRY-1 physically interacts with BAR-1, SGG-1, APR-1, and AXL-1; PRY-1 reporter fusion proteins are expressed in hypodermal and neuronal lineages where they typically localize asymmetrically to the anterior cortex.
GO Process (17)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- anterior/posterior axis specification [IMP]
- anterior/posterior pattern specification [IMP]
- axon guidance [IMP]
- axonal fasciculation [IMP]
- canonical Wnt signaling pathway [IMP]
- cell migration [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- mitotic spindle organization [IMP]
- negative regulation of Wnt signaling pathway [IGI]
- negative regulation of vulval development [IGI, IMP]
- nematode larval development [IMP]
- oviposition [IMP]
- positive regulation of multicellular organism growth [IMP]
- regulation of cell fate specification [IMP]
- regulation of protein localization [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Download Curated Data for this Protein
38675
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- Interactors 39
- Interactions 49
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