CELE_F33G12.4, F33G12.4

lrr-1 encodes a leucine rich repeat-containing protein that also contains a BC/Cul-2 box; lrr-1 activity is required for regulating the extent of DNA replication during S phase and hence, normal cell cycle progression, in both the germ line and the early embryo; specifically, LRR-1 is predicted to function as a substrate-recognition subunit of a Cullin-RING E3 ubiquitin ligase complex, as LRR-1 forms a complex in vitro with ELC-1 and ELB-1, and interacts in vivo with CUL-2; LRR-1 localizes to the nucleus throughout the germ line and in early embryos; LRR-1's nuclear localization is dependent upon CUL-2 and ELB-1.

39220

6239