CELE_C17G10.5, C17G10.5

lys-8 encodes a putative lysozyme required for normal longevity, probably because it prevents killing of C. elegans by bacteria infecting its gut; LYS-8 is expressed in intestine up to the terminal bulb of the pharynx, as well as in g1 and g2 pharyngeal gland cells; LYS-8 expression is induced by infection with Serratia marcescens, Pseudomonas aeruginosa, or (weakly) by Microbacterium nematophilum; LYS-8 expression is promoted by DBL-1, TIR-1 and NSY-1; lys-8 transcripts are increased by both DBL-1 and SMA-2 (though not strongly affected by LON-2), perhaps reflecting a general role of the DBL-1 signalling pathway in activating intestinal genes and susceptibility of dbl-1 mutants to infection; lys-8 transcripts are repressed by DAF-2 (and thus presumably increased by DAF-16), and lys-8(RNAi) animals display reduced lifespan; induction of LSY-8 by any of three different Gram-negative bacteria (E. coli, S. marcescens, or P. aeruginosa) requires DAF-16, DBL-1, and NSY-1; LSY-8 and its paralogs (LYS-1 to -7 and LYS-10) are more similar to lysozymes from the amoeboid protozoon Entamoeba histolytica than to more familiar ones from vertebrates.

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