Caenorhabditis elegans
FBF-2
CELE_F21H12.5, F21H12.5
fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages.
GO Process (13)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- embryo development ending in birth or egg hatching [IMP]
- feminization of hermaphroditic germ-line [IMP]
- germ cell development [IMP]
- germline cell cycle switching, mitotic to meiotic cell cycle [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- masculinization of hermaphroditic germ-line [IMP]
- meiotic chromosome segregation [IMP]
- negative regulation of translation [IGI]
- negative regulation of vulval development [IMP]
- receptor-mediated endocytosis [IMP]
- reproduction [IMP]
- spermatogenesis [IMP]
Gene Ontology Molecular Function
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- Interactors 34
- Interactions 49
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