Caenorhabditis elegans
SMA-6
CELE_C32D5.2, C32D5.2
sma-6 encodes a serine/threonine protein kinase that is orthologous to type I TGF-beta receptors; sma-6 activity is required for regulating body length and for proper development of the male tail; sma-6, along with other genes in the TGF-beta Sma/Mab pathway, also regulates reproductive aging; a reduction of TGF-beta pathway genes extends reproductive span by maintaining oocyte and germline quality; sma-6 expression first begins at the 1.5-fold stage of embryogenesis and continues through adulthood; sma-6 is expressed in dorsal and ventral hypodermis, pharyngeal muscle, and the intestine; expression in the hypodermis is necessary and sufficient for body length regulation.
GO Process (13)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- BMP signaling pathway [ISS]
- body morphogenesis [IMP]
- dauer larval development [IGI]
- defense response to fungus [IMP]
- innate immune response [IMP]
- maintenance of protein location in nucleus [IMP]
- nematode male tail tip morphogenesis [IGI, IMP]
- positive regulation of multicellular organism growth [IGI, IMP]
- positive regulation of protein catabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of cell adhesion [IMP]
- regulation of cell morphogenesis [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
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- Interactors 87
- Interactions 90
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