CELE_F18A1.5, F18A1.5

rpa-1 encodes the C. elegans ortholog of the replication protein A (RPA) large subunit; by homology, RPA-1 is predicted to function as a DNA-binding and oligonucleotide oligosaccharide-binding (OB) protein that is required for DNA replication, repair, and recombination; large-scale RNAi screens indicate that rpa-1 is essential for embryonic development; RPA-1 physically interacts with RPA-2, the RPA medium subunit, in vivo; in situ hybridization studies indicate that rpa-1 transcripts are expressed in germ cells.

39572

6239