CELE_D2013.5, mgm-1, D2013.5

eat-3 encodes a mitochondrial dynamin family member, closely related to bacterial dynamin-like proteins, that is orthologous to human Opa1 (OMIM:203740, mutated in autosomal dominant optic atrophy) and budding yeast Mgm1; eat-3 is required for proper regulation of inner mitochondrial membrane fusion and normal mitochondrial function (oxidative phosphorylation); accordingly, eat-3 is also required for normal body size, growth rates, locomotion, and reproductive levels; eat-3 promoter fusions are expressed at high levels in the intestine, muscles, and neurons, with lower levels seen in other cell types; by similarity to its mammalian and yeast orthologs, EAT-3 is predicted to localize to the mitochondrial intermembrane space.

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