CELE_VW02B12L.3, VW02B12L.3

ebp-2 encodes an RP/EB-type microtubule-binding protein orthologous to human MAPRE1 (OMIM:603108), MAPRE2 (OMIM:605789), MAPRE3 (OMIM:605788), and paralogous to EBP-1/-3; EBP-2 binds the plus ends of growing microtubules; by orthology, the N-terminal calponin homology domain of EBP-2 is predicted to bind microtubules (MTs), while the C-terminal region of EBP-2 is predicted to contain a dimerization domain and a site for binding protein ligands that activate EBP-2's MT-binding; ebp-2(RNAi) animals have no obvious phenotypes, perhaps because of genetic redundancy with ebp-1 and ebp-3.

40051

6239