CELE_K04B12.1, cep-1, K04B12.1

plx-2 encodes one of two C. elegans plexins, conserved transmembrane proteins that function as semaphorin receptors in both vertebrates and invertebrates; plx-2 activity is essential for proper male tail and epidermal morphogenesis and for normal axon guidance in a select group of neurons, including SDQL; genetic analyses indicate that plx-2 functions with mab-20/semaphorin-2a, efn-4/ephrin-4, and unc-129/TGF-beta to regulate male tail morphogenesis and with mab-20 and lad-2/L1CAM to mediate axon guidance; PLX-2 can bind MAB-20 and this interaction is enhanced in the presence of LAD-2; PLX-2::GFP reporters are expressed in a subset of neurons and epidermal cells, as well as a subset (1, 3, 5, and 7) of male sensory ray cell clusters.

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