Caenorhabditis elegans
TAC-1
CELE_Y54E2A.3, 2P40, Y54E2A.3
tac-1 encodes the sole C. elegans member of the transforming acidic coiled-coil (TACC) protein family whose members contain highly conserved C-terminal coiled-coil domains; during early embryogenesis, TAC-1 activity is essential for such microtubule-based processes as pronuclear migration and mitotic spindle elongation; TAC-1 interacts in vivo with, and mutually stabilizes, ZYG-9, a microtubule-associated protein (MAP) also required for pronuclear migration; TAC-1 also interacts with ZYG-8, a kinase domain-containing MAP required for proper spindle positioning during anaphase of the first embryonic cell division; TAC-1 is a core component of centrosomes, and also localizes to the meiotic spindle poles, the mitotic spindle, and the cytoplasm.
GO Process (14)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
- astral microtubule organization [IMP]
- body morphogenesis [IMP]
- cell division [IMP]
- collagen and cuticulin-based cuticle development [IMP]
- embryo development ending in birth or egg hatching [IMP]
- locomotion [IMP]
- meiotic chromosome segregation [IMP]
- meiotic nuclear division [IMP]
- microtubule polymerization [IMP]
- mitotic spindle elongation [IMP]
- mitotic spindle organization [IMP]
- negative regulation of microtubule depolymerization [IMP]
- pronuclear migration [IMP]
- regulation of microtubule polymerization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
40414
6239
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- Interactors 53
- Interactions 71
- Network