CELE_C44B11.3, Alpha-tubulin, tba-3, C44B11.3

mec-12 encodes an alpha-tubulin; MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons; mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons; MEC-12 is acetylated in a manner that is dependent upon MEC-17 and W06B11.1, which encode paralogous alpha-tubulin acetyltransferases.

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