CELE_C16C10.10, tag-73, C16C10.10

glod-4 encodes a glyoxalase required for normal lifespan, orthologous to human GLOD4; GLOD-4 is expressed in the larval and adult pharynx, pharyngeal-intestinal valve, intestine, anal sphincter, seam cells, amphids, and neurons, and in the adult reproductive system; overexpression of GLOD-4 increases glyoxalase activity 200-fold, reduces oxidative stress markers, and extends lifespan, probably by removing methylglyoxal from mitochondrial proteins, while glod-4(RNAi) animals exhibit increased methylglyoxalation of mitochondrial proteins and reduced lifespan; GLOD-4 activity normally decreases in vivo with age, despite unchanged levels of glod-4 mRNA.

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