CELE_C16C10.6, C16C10.6

ccdc-55 encodes a conserved coiled-coil domain-containing protein that is related to the mammalian nuclear speckle splicing regulatory proteins 1 (NSrp1s); in C. elegans, CCDC-55 activity is required for early larval development and also for distal tip cell (DTC) migration; cell type-specific RNAi experiments suggest that CCDC-55 functions within the DTC to regulates its migration; genetic interactions suggest that CCDC-55 functions at least partially in parallel with the E3 ubiquitin ligases RNF-5 and RNF-121 to regulate DTC migration; when expressed in the DTC, CCDC-55 localizes to the cytoplasm and the nucleus.

40770

6239